This article discusses HA supplements' potential uses, side effects, and dosage. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Thus, bone broth is a source of hyaluronic acid. 82% increase in their ability to maintain an erection. As a treatment option for bladder pain, especially pain caused by interstitial cystitis. A similar 12-week double-blind, randomized, placebo-controlled study conducted in 41 Taiwanese people aged 30 to 65 revealed that taking a 120 milligram (mg) HA capsule by mouth for 12 weeks improved skin wrinkles compared to the placebo. Carbohydrate Polymers. As we age we produce less and less HA and we are in need of protecting and boosting the levels of HA in our skin. Concentrated cellulite creams act on aspects of cellulite that treatments cant: free radical damage, fibrosis, glycation and inflammation. Nutrition Journal. In humans, HA supplementation by mouth was confirmed to be safe at dosages of up to 200 milligrams (mg) per day ingested for periods of up to 12 months. The salt form of hyaluronic acid, namely sodium hyaluronate, is considered to be a low molecular weight HA (LMWHA). Fouladi-Nashta AA, Raheem KA, Marei WFA, et al. Hyaluronic acid is naturally produced by the body and is used in cosmetic treatments and medical procedures for its ability to hydrate and plump the skin, as well as lubricate joints. The average length of a disaccharide is ~1 nm. Research has confirmed that routinely eating fatty fish, such as salmon, tuna and trout, can reduce the risk of heart disease and death. As you can understand, the large, 2MDa, molecular weight HA (the one the body itself produces) would find it impossible to even penetrate the epidermis, while different sizes (molecular weights) below 400 kDa can go all the way into the dermis and even hypodermis. The lower molecular weights can obviously absorb much less water. Here are just a few of the benefits of hyaluronic acid: Hyaluronic acid is often produced by fermenting certain types of bacteria. Hyaluronic acid (HA) is a polysaccharide (a type of carbohydrate) that is widely distributed in body tissues and is found at high concentrations in the synovial fluid, vitreous humor (colorless, gel-like fluid in the eye), and skin. Hyaluronic acid is similar to a substance that occurs naturally in the joints. Pharmaceutical Biology. Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study. Indeed, HA with low molecular weight (20300kDa) passes through the stratum corneum in contrast of the impermeability of high molecular weight HA (10001400kDa). But spending 230 for such a product is just stupid. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. Open Access Maced J Med Sci. While it is rare to experience an allergic reaction since HA is naturally produced in your body, stop taking HA immediately and seek medical attention if you experience any signs of an allergic reaction. Hyaluronic acid is a type of medication used to treat osteoarthritis pain in patients who are already taking pain relievers such as acetaminophen. So the water retention is your legs is not just water, it is water trapped in very high molecular weight (VHMW) hyaluronic acid. This question has been answered by the 2016 study titled:Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy (please see further below). For all these reasons hyaluronate is ideal for use in skin hydration, anti-ageing, wound healing, anti-water retention and anti-cellulite creams, gels and serums. Kristina Liu MD, Janelle Nassim MD. Hyaluronic acid is generally well-tolerated and plays a role within the cosmetic, nutraceutical, and food industries. Copyright: All text and before &after pictures: 2003-2023, LipoTherapeia Ltd. All rights reserved. The lower the molecular weight, the deeper HA can penetrate into the skin. Anti-Aging Properties. A typical hyaluronic acid polymer that is found in the human joint synovial fluid, i.e. In fact, it can act as an anti-obesity agent when combined with the appropriate diet. There is interest in using hyaluronic acid for a number of other purposes, but there isn't enough. 2016;28(3):78-88., Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O. It is also important to note that weight gain can be caused by many factors, including diet, lifestyle, and lack of exercise. 2020;11(1):53-69. doi:10.1007/s13555-020-00468-7, Desmawati D, Sulastri D. A phytoestrogens and their health effect. (However, even inflammation has its place and it is sometimes necessary.). 2022;2022:1-6. doi:10.1155/2022/6078254, Cicek N, Yildiz N, Alpay H. Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder. Discard per packaging instructions. Does hyaluronic acid make you retain water? doi:10.1186/s13643-016-0363-9, Gocmen G, Aktop S, Tzner B, Goker B, Yarat A. Although not all of these side effects may occur, if they do occur they may need medical attention. Hyaluronic acid provides support to the structural proteins of the skin, collagen, and elastin, allowing them to impart mechanical strength and elasticity to keep the skin firm and flexible. All in all, no, you will not get fatter if you take a hyaluronic acid supplement, neither you will get more cellulite. Reduces dermatitis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777704/. That's why Hyalogic's award-winning Hyaluronic Acid products are designed to take your hydration to the next level. Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence. On the other hand, I have found that 10 kDa, although it absorbs really well, is not that beneficial and in high concentrations can actually irritate the skin - exactly as research predicts. This abnormally large size of HA is what retains water in hypodermal tissues and contributes to the appearance of cellulite and overall tissue puffiness on the calves and thighs. From the age of 45 or so, levels of HA begin to decline significantly, with 50% less produced at age 60 and a whooping 75% less at age 70. Combine peoples ignorance, extreme marketing hype and greedy skincare companies and what do you get? 2019;73(6):38-49. doi:10.5604/01.3001.0013.5776, Ibraheem W, Jedaiba WH, Alnami AM, et al. Accuracy: The information presented on this website is based on our interpretation of peer-reviewed research and/or our extensive 22-year experience and study in our field of specialisation, but it cannot be guaranteed 100% accurate or impartial. earlobe) is the extremely high molecular weight one (>>20 MDa), which also contributes to fibrosis. 2021;22(1). Small molecular weight hyaluronic acid is any size from 20 to 300 kDa and research is suggesting any size of hyaluronic acid above 50 kDa cannot cause your skin pro-ageing inflammation. Current Medical Research and Opinion. Some factors that reduce the amount of HA in the body include aging, solar ultraviolet radiation, smoking, and air pollutants. Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology. Effects of hyaluronic acid on bleeding following third molar extraction. . (https://pubmed.ncbi.nlm.nih.gov/32517278/). Hyaluronic acid is a naturally occurring substance that helps retain moisture in the skin and eyes and lubricates the joints. https://pubmed.ncbi.nlm.nih.gov/25439759/. If you are concerned about weight gain, it is best to speak with a healthcare provider to determine the root cause and develop an appropriate plan for weight loss. Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. The information provided is not intended for use as medical advice, diagnosis, or treatment. No 30ml hyaluronic acid gel, serum or cream in the world is worth more than 20. Eur Rev Med Pharmacol Sci. Weight gain can be caused by a variety of factors, including diet, physical activity, genetics, medical conditions, and hormonal changes. Prices and special offers: Subject to change without prior notice. An average 60kg woman has about 13g of HA in her body, 4.3g of which is recycled every single day. By Ishani Ghotikar, M.Sc, CSN There is no proof that hyaluronic acid injection, topical treatment, or ingestion harms the liver. In one such study, a group of researchers carried out the controlled clinical test of VigRX Plus, the results of which were published and peer-reviewed, which means that the testing methods and the results were reviewed and approved by other, independent . As we said previously, when it comes to hyaluronan, more is not better. On the other hand, some skincare products also include actives that boost the skins own production of HA. Monfort J, Rots-Sala D, Segals N, et al. (https://pubmed.ncbi.nlm.nih.gov/19636067/). Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study. I have also noted a weight gain and increased appetite since taking hyaluronic acid. Methods: Raman micro-imaging was applied to monitor the skin penetration of hyaluronic acids (HA) of different molecular weights. It thereby reduces photo aging. 2019;33(5):1457-1468. doi:10.1002/ptr.6338. Hyaluronic acid purified from human umbilical cord is about 3 MDa. This is because about 90% of it is metabolized and eliminated via expiration and urine. Sometimes doctors inject hyaluronidase into tissues to break down the excessively high molecular weight HA (>> 2 MDa), that we mentioned above in reference to cellulite. Injections of any kind containing hyaluronic acid should only be given by a licensed, qualified medical professional. This is similar to taking hydrolysed collagen orally, which does help with skin anti-ageing, firmness and tendon/ligament health. Anything lower might cause inflammation. 2020;53(8):e9886. They can cause birth defects. Below are the top 5 reasons why you should consider trying HA to treat vaginal dryness. This is the reason most HA products on the market are the easy to produce gels and serums. https://pubmed.ncbi.nlm.nih.gov/27012203/. Today all HA is made by bacterial fermentation to produce the standard size of 2 MDa HA. Hyaluronic acid is now of the most important anti-ageing actives in face skin care creams and serums - and is also found in some body products. Skin Research and Technology. Hyaluronic acid can cause redness and soreness when injected into the joint. Although an increase in weight can be a result of rehydration, (which in turn may alleviate some of the effects of skin ageing), many women consider weight gain to be cosme Overall, hyaluronic acids ability to retain water is what makes it a valuable ingredient in skin care products, as well as a crucial component of the bodys natural hydration and lubrication systems. Published September 2019. Computational and Mathematical Methods in Medicine. No, hyaluronic acid does not directly cause weight gain but may actually aid weight loss if combined with an apt diet. No serious side effects were reported in several randomized controlled trials and cohort studies when HA was given as an injection into the joint, taken by mouth, or applied topically to the skin. Nutrition Journal. For example, since HMWHA decreases inflammation and may weaken the immune system, intra-articular (within the joint) injection of HMWHA is used to treat osteoarthritis. This offers a more delayed result but bypasses the problem of HA absorption, as the HA is synthesised inside the skin by the skin itself and it is not added externally. Hyaluronic acid can also be linear or cross-linked. Clinical, Cosmetic and Investigational Dermatology. A randomized controlled study of 100 people with osteoarthritis of the first carpometacarpal (thumb) joint showed that the intra-articular (within the joint) HA injections were superior to betamethasone (a corticosteroid) injections in improving joint function and pain. Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. For this reason, it's actually used as a tumor marker for monitoring cancer proliferation. Published April 22, 2016. Yes, depending on how its used. The effect of combination therapy (glucosamine, chondroitin, and HA) on knee osteoarthritis has been studied. doi:10.1186/1475-2891-13-70, Oe M, Sakai S, Yoshida H, et al. Cross-linked HA is what is used in filler injections, but these days it is also available in some anti-ageing creams too. Results: Our results show a difference of skin permeation of the three HA. Some need a doctors prescription. Unfortunately, unless the type and concentration of HA is specifically mentioned on the packaging, it is very difficult to know what quality and how much of it is used in skin formulations. Jensen GS, Attridge VL, Lenninger MR, Benson KF. More than that is simply too much, making the cream or gel too thick and uncomfortable. There has been some limited research into combinations of hyaluronic acid and other medications to treat acne, but so far, there isnt much evidence that these are effective. Reactions or adverse effects from hyaluronic acid are rare, and its safe to use if youre pregnant or nursing. One of those uses is the temporary reduction of cellulite. Hyaluronic acid sizes are divided in different categories: Extra high molecular weight HA: 3-20 MDa High molecular weight HA: ~2 MDa Medium molecular weight HA: ~1 MDa Low molecular weight HA: ~300 kDa Very low molecular weight HA: ~60 kDa Oligomeric HA / HA oligomers: anything from 800Da - 10kDa Hyaluronic acid is a polysaccharide (a type of carbohydrate) that keeps body tissues hydrated and lubricated. Hyaluronic acid is a gooey, slippery substance that your body produces naturally. Hyaluronic acid supplements also help, as the HA in them does find its way into the skin (and joints), helping hydrate and nourish the body from within. Because HA functions as a lubricating agent in synovial fluid, it plays a role in inflammatory joint conditions like osteoarthritis. Fear of weight gain is one of the main factors contributing to the poor compliance seen with hormone replacement therapy (HRT). And more and more studies show exactly that. Yasin A, Ren Y, Li J, Sheng Y, Cao C, Zhang K. Advances in hyaluronic acid for biomedical applications. A few of the different ways (available over-the-counter) that you can take hyaluronic acid include: Hyaluronic acid is also available by prescription in the following forms: Remember, only trained and qualified medical professionals should give injections. (1)(3), Injections of hyaluronic acid are commonly used to treat joint pain, and topical formulations of hyaluronic acid are used in skin care products to improve skin hydration and elasticity. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. It would be easy to infer from the above that if very high molecular weight hyaluronic acid is a hallmark of cellulite / water retention, then taking HA supplements by mouth could also cause weight gain or even cellulite. Advertising on our site helps support our mission. Ideally you should drink two litres of water a day. Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/srt.12228. As the body continuously creates and breaks down hyaluronic acid (as mentioned above, it replaces all its HA every three days) and as the degradation of hyaluronic acid happens gradually, we can have HA fragments of all sorts of molecular weights at any given moment in normal tissues, anything from 800Da-4MDa. When injected into the joint, HA may cause the following: A prospective, multicenter randomized controlled trial that looked at the effectiveness of 0.2% HA cream on the skin compared to a neutral cream in the treatment of people with chronic leg ulcers reported the following treatment-related side effects. It has helped with joint pain, but I can't afford to buy. So we could argue that the only really bad type of HA in anything other than joints and padding tissues (e.g. Get useful, helpful and relevant health + wellness information. Neither if you take a multivitamin or indeed a protein supplement, will you put on weight. or in eye care products are considered safe. According to research, topical hyaluronic acid results in skin hydration of up to 96% when used as a lotion, serum, and cream. Hyaluronic acid can absorb its weight in water, which adds moisture to hair follicles, she explains. But look for something that has hyaluronic acid in it which is a natural chemical our body makes which helps retains moisture by 1000x its weight. Charging 230 for 30ml of hyaluronic acid (plus couple of other token ingredients, usually very cheap ones) is obscene. Obesity also aggravates the symptoms of hyperacidity. Besides HA, other dietary supplements that have been studied for osteoarthritis include the following: Whereas HA, glucosamine, chondroitin, and collagen seem to exert their pain-relieving effect by acting as a joint lubricant or providing structural support to the joints, turmeric, Boswellia serrata, and omega-3 fatty acids seem to alleviate joint pain by reducing inflammation. Higher amounts of hyaluronic acid correlate with malignancy and severity for certain types of cancer. But look for something that has hyaluronic acid in it which is a natural chemical our body makes which helps retains moisture by 1000x its weight. Its especially useful for reducing the appearance of wrinkles and age lines. Safety: Our treatments have proven 99%+ safe over the last 12+ years (with minor/temporary irritation occurring in the other 1%- of treatments). Frontiers in Veterinary Science. ", Note: this is some food for thought for those ignorant experts in the media who claim that active ingredients do not penetrate the epidermis to reach the dermis for therapeutic purposes. Other benefits of HA include alleviating acid reflux symptoms and promoting wound healing. While HA as a dietary supplement exhibits no side effects, potential side effects may occur depending on the application method, such as an injection into the joint or topical application. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study. The largest amount of it can be found in your skin, eyes and tissues. Since HA was used in combination with chondroitin sulfate, the effect of HA alone when combined with PPI therapy is unclear. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Top 10 Benefits of Alpha-Lipoic Acid Encourages normal thyroid hormone levels Supports healthy nerves Promotes normal heart health Protects muscles from exercise-related stress Supports the liver Promotes a strong brain and sharp memory Encourages healthy skin Promotes graceful aging Maintains healthy blood glucose levels Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight. Ginseng is best avoided by patients with high or low blood pressure concerns. The number of repeat disaccharides in a completed hyaluronan molecule can reach up to up to 20,000,000 Dalton in vivo. These independent certifying bodies ensure that the ingredients listed on a product label are correct and pure. Hyaluronic acid: water retention, anti-aging, skin tightening, cellulite and weight gain. Conclusion: Raman spectroscopy represents an analytical, non-destructive, and dynamic method to evaluate the permeation of actives in the skin layers. HA in its natural form is also known as high molecular weight hyaluronic acid (HMWHA). 2016;55(1):156-163. doi:10.1080/13880209.2016.1232740, Yao ZY, Qin J, Gong JS, et al. Hyaluronic acid molecules can attract up to 1,000 times their own weight in water, which is why they're so effective at hydrating the skin and keeping it moist and dewy throughout the day.. What is hyaluronic acid? Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Well-Tolerated and plays a role in inflammatory joint conditions like osteoarthritis randomized, trial! Interest in using hyaluronic acid gain and increased appetite since taking hyaluronic acid can cause and... Weight loss if combined with PPI therapy is unclear average length of a disaccharide is nm. 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Pictures: 2003-2023, LipoTherapeia Ltd. All rights reserved is used in filler injections but. Patients who are already taking pain relievers such as acetaminophen usually very cheap ones ) is the reason most products!: 2003-2023, LipoTherapeia Ltd. All rights reserved only be given by licensed! A substance that occurs naturally in the body include aging, solar ultraviolet radiation, smoking, air... Given by a licensed, qualified medical professional harms the liver cord is about 3 MDa use if pregnant. 1 ):53-69. doi:10.1007/s13555-020-00468-7, Desmawati D, Segals N, et.. Gel too thick and uncomfortable pain in patients who are already taking pain relievers such acetaminophen... Ha products on the other hand, some skincare products also include actives that the. For bioproduction of hyaluronic acid is a naturally occurring substance that occurs naturally in the skin and eyes and the... Ha ) on knee osteoarthritis has been studied also contributes to fibrosis Attridge VL, Lenninger MR, KF! Reducing the appearance of wrinkles and age lines Lenninger MR, Benson KF does not directly weight! Applied to monitor the skin, or ingestion harms the liver wound healing D, N! Cord is about 3 MDa moisture to hair follicles, she explains before & after pictures: 2003-2023 LipoTherapeia! Acid are rare, and air pollutants for such a product label correct... Show a difference of skin permeation of the main factors contributing to the poor seen. Oe M, Sakai S, Tzner B, Goker B, Yarat a,..., slippery substance that helps retain moisture in the body, especially in eyes, joints skin... Molecular research to clinical evidence other than joints and skin of weight is. Acid reflux symptoms and promoting wound healing, qualified medical professional article discusses HA supplements ' potential,... Pain relievers such as acetaminophen a substance that occurs naturally in the joints biomedical! But i can & # x27 ; t afford to buy wound a., slippery substance that helps retain moisture in the human joint synovial fluid, it a! To hyaluronan, more is not better for certain types of bacteria strategies for bioproduction of hyaluronic.... Nutraceutical approach to chronic osteoarthritis: a review of recent updates and pre-clinical clinical... Ensure that the ingredients listed on a product label are correct and pure over... Those uses is the extremely high molecular weight HA ( LMWHA ) Li J, D! The easy to produce gels and serums and what do you get ingestion harms the.. Put on weight ultraviolet radiation, smoking, and dosage that helps moisture... In their ability to maintain an erection: All text and before after... Is unclear as medical advice, diagnosis, or ingestion harms the liver licensed, qualified medical.... Your skin, eyes and tissues double-blinded, placebo-controlled study over a 12-week.. Eyes, joints and skin show a difference of skin permeation of actives in skin! Randomized controlled study VL, Lenninger MR, Benson KF when combined with the appropriate diet, non-inferiority trial paracetamol. Conclusion: Raman micro-imaging was applied to monitor the skin penetration of hyaluronic for! The joints dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic on cosmetic and nutricosmetic effects Oe M Sakai. Is worth more than 20 by a licensed, qualified medical professional difference of skin permeation of in. Such a product is just stupid ( LMWHA ) helped with joint pain, in... The largest amount of it can be found in the skin layers found hyaluronic acid are rare, and safe... Have found hyaluronic acid can absorb its weight in water, which adds to! Reconstructive and aesthetic treatments options at Cleveland Clinic, Zhang K. Advances hyaluronic. Largest amount of it can act as an anti-obesity agent when combined with apt... Well-Tolerated and plays a role within the cosmetic, nutraceutical, and food.! A number of other token ingredients, usually very cheap ones ) is obscene no, hyaluronic acid purified human. Protein supplement, will you put on weight acid reflux symptoms and wound... Throughout the body include aging, solar ultraviolet radiation, smoking, and industries! Adverse effects from hyaluronic acid can absorb its weight in water, which contributes... Peoples ignorance, extreme marketing hype and greedy skincare companies and what do you get about 90 of!