Once youve assessed tolerance and effect, you may increase your dose in a stepwise fashion. This will help you choose the right product. These side effects are usually mild, yet if you experience them, they are often a sign that you have too much choline in your body. The way you take Alpha-GPC for cognitive enhancement will depend on your goals. Two common types are CDP-Choline (Citicoline) and Choline Bitartrate / Lecithin. How Do You Take Alpha-GPC For Cognitive Enhancement? Heres an example of an alpha GPC stack that includes the popular nootropic Noopept and a racetam, aniracetam. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. However, it is banned by some athletic organizations. First, make sure you're buying from a reputable source. Choline bitartrate, while cheaper, does not raise neural Choline levels. See our medical disclaimer. Alpha GPC is naturally present in the body in small amounts, and it is also commercially manufactured as a supplement using purified soy lecithin. There have been numerous studies conducted which speak to the effectiveness of Alpha GPC in achieving the benefits examined above. This is significant to focus because dopamine is "motivation" at a chemical level. In clinical studies, alpha-GPC dosage ranged from 250 to 1,200mg/day. Should you stack Huperzine A and Alpha-GPC? Alpha-GPC is more bioavailable than Choline Bitartrate, but both are more bioavailable than CDP-Choline. The focus of this article is on helping you decide whether Alpha-GPC is a substance that you should consider adding to your diet, or to your existing supplement routine. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Alpha-GPC is considered GRAS (Generally Recognized As Safe) by the FDA. Alpha-GPC's half-life is 4-6 hours. Alpha-GPC is a choline supplement that boosts the neurotransmitter acetylcholine in the brain. Alpha GPC is generally well tolerated when taken at recommended dosages. Other studies have suggested that Alpha GPC can improve memory formation as well as learning ability. NooCube is our top-rated cognitive enhancer, and it contains a range of powerful nootropics that work together to enhance cognitive function. View abstract. CDP Choline also breaks down into Uridine: This is the reason why Citicoline is only 18.5% Choline by weight. [8] The No Observed Adverse Effect Level is 150 mg per kg of body weight per day. The multiple administrations are important in order to combat the fact that Piracetam has a very short 2 or three hour half-life. Executive function means our ability to plan, organize and manage time. Enea Traini, Vincenzo Bramanti, Francesco Amenta, G Gatti, N Barzaghi, G Acuto, G Abbiati, T Fossati, E Perucca, Lena Marcus, Jason Soileau, Lawrence W Judge, David Bellar, David Bellar, Nina R LeBlanc, Brian Campbell, Amy M Brownawell, Edward L Carmines, Federica Montesano, Gyeongsil Lee, Seulggie Choi, Jooyoung Chang, Daein Choi, Joung Sik Son, Kyuwoong Kim, Sung Min Kim, Seogsong Jeong, Sang Min Park, Zeneng Wang, Jennie Hazen, Xun Jia, Elin Org, Yongzhong Zhao, Lucas J Osborn, Nisreen Nimer, Jennifer Buffa, Miranda K Culley, Daniel Krajcik, Bert-Jan H van den Born, Koos Zwinderman, Bruce S Levison, Max Nieuwdorp, Aldons J Lusis, Joseph A DiDonato, Stanley L Hazen, Seyed Khosrow Tayebati, Daniele Tomassoni, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco Amenta, Francesco Amenta, Seyed Khosrow Tayebati, Daniela Vitali, Maria Antonietta Di Tullio, C M Lopez, S Govoni, F Battaini, S Bergamaschi, A Longoni, C Giaroni, M Trabucchi, Tayebati SK, Tomassoni D, Nwankwo IE, Di Stefano A, Sozio P, Cerasa LS, Amenta F, Armah CN, Sharp P, Mellon FA, Pariagh S, Lund EK, Dainty JR, Teucher B, Fairweather-Tait SJ, Gatti G, Barzaghi N, Acuto G, Abbiati G, Fossati T, Perucca E, Parnetti L, Mignini F, Tomassoni D, Traini E, Amenta F, Di Perri R, Coppola G, Ambrosio LA, Grasso A, Puca FM, Rizzo M, Amenta F, Tayebati SK, Vitali D, Di Tullio MA, Tayebati SK, Di Tullio MA, Tomassoni D, Amenta F, Amenta F, Carotenuto A, Fasanaro AM, Rea R, Traini E, Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M, Klein J, Gonzalez R, Kppen A, Lffelholz K, Abbiati G, Fossati T, Lachmann G, Bergamaschi M, Castiglioni C, Sigala S, Imperato A, Rizzonelli P, Casolini P, Missale C, Spano P, Aleppo G, Nicoletti F, Sortino MA, Casabona G, Scapagnini U, Canonico PL, Schettini G, Ventra C, Florio T, Grimaldi M, Meucci O, Scorziello A, Postiglione A, Marino A, Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M, Tayebati SK, Tomassoni D, Di Stefano A, Sozio P, Cerasa LS, Amenta F, Tomassoni D, Catalani A, Cinque C, Di Tullio MA, Tayebati SK, Cadoni A, Nwankwo IE, Traini E, Amenta F, Canal N, Franceschi M, Alberoni M, Castiglioni C, De Moliner P, Longoni A, Ferraro L, Tanganelli S, Marani L, Bianchi C, Beani L, Siniscalchi A, Beani L, Bianchi C, Tanganelli S, Antonelli T, Simonato M, Rando S, Hoffman JR, Ratamess NA, Gonzalez A, Beller NA, Hoffman MW, Olson M, Purpura M, Jger R, Nelson TJ, Sun MK, Hongpaisan J, Alkon DL, Ren SQ, Yan JZ, Zhang XY, Bu YF, Pan WW, Yao W, Tian T, Lu W, Govoni S, Battaini F, Lucchi L, Pascale A, Trabucchi M, Lucchi L, Pascale A, Battaini F, Govoni S, Trabucchi M, Govoni S, Lucchi L, Battaini F, Trabucchi M, Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wurtman RJ, Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J, Yang X, Sheng W, He Y, Cui J, Haidekker MA, Sun GY, Lee JC, Gentile MT, Reccia MG, Sorrentino PP, Vitale E, Sorrentino G, Puca AA, Colucci-D'Amato L, Milanesi L, Sheynis T, Xue WF, Orlova EV, Hellewell AL, Jelinek R, Hewitt EW, Radford SE, Saibil HR, Parnetti L, Abate G, Bartorelli L, Cucinotta D, Cuzzupoli M, Maggioni M, Villardita C, Senin U, Barbagallo Sangiorgi G, Barbagallo M, Giordano M, Meli M, Panzarasa R, Ceda GP, Ceresini G, Denti L, Marzani G, Piovani E, Banchini A, Tarditi E, Valenti G, Agarwal N, Sung YH, Jensen JE, daCunha G, Harper D, Olson D, Renshaw PF, Babb SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, Renshaw PF, Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA, Hurrell RF, Reddy MB, Juillerat M, Cook JD, Troesch B, Egli I, Zeder C, Hurrell RF, de Pee S, Zimmermann MB, Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent, A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers, Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial, The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility, Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance, The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength, Safety assessment of AGPC as a food ingredient, Impact of trimethylamine N-oxide (TMAO) metaorganismal pathway on cardiovascular disease, Association of L- Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years, The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis, Effect of choline-containing phospholipids on brain cholinergic transporters in the rat, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission, Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drug, Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine, Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain, Dietary choline: biochemistry, physiology, and pharmacology, Revisiting choline alphoscerate profile: a new, perspective, role in dementia, Purification of L-alpha glycerylphosphorylcholine by column chromatography, L-alpha-glycerophosphocholine contributes to meat's enhancement of nonheme iron absorption, The isolation of alpha-glycerylphosphorylcholine from incubated beef pancreas; its significance for the intermediary metabolism of lecithin, Simplified preparation of L-alpha-glyceryl phosphoryl choline, Concentrations of Choline-Containing Compounds and Betaine in Common Foods, Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation, A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia, Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats, The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: interim results, Studies on the phospholipases of rat intestinal mucosa, Lecithinase and lysolecithinase of intestinal mucosa, The mechanism of intestinal absorption of phosphatidylcholine in rats, The transphosphatidylation activity of phospholipase D, Intestinal absorption of polyunsaturated phosphatidylcholine in the rat, Transesterification of lysolecithin in the intestinal mucosa of rats, Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults, Choline-containing phospholipids: relevance to brain functional pathways, Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain, Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids, Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of {14C}-L-alpha-glycerylphosphorylcholine, L-alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat, Chronic L-alpha-glyceryl-phosphoryl-choline increases inositol phosphate formation in brain slices and neuronal cultures, Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats, Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats, Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine, Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by alpha-glycerylphosphorylcholine, Noradrenergic modulation of cortical acetylcholine release is both direct and gamma-aminobutyric acid-mediated, Inversion of the alpha-2 and alpha-1 noradrenergic control of the cortical release of acetylcholine and gamma-aminobutyric acid in morphine-tolerant guinea pigs, The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students, Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair, PKC is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP, PKC translocation in rat brain cortex is promoted in vivo and in vitro by alpha-glycerylphosphorylcholine, a cognition-enhancing drug, Cognition stimulating drugs modulate protein kinase C activity in cerebral cortex and hippocampus of adult rats, PKD at the crossroads of DAG and PKC signaling, Protein kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs, Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease, Choline metabolism as a basis for the selective vulnerability of cholinergic neurons, "Autocannibalism" of choline-containing membrane phospholipids in the pathogenesis of Alzheimer's disease-A hypothesis, Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients, Secretory phospholipase A2 type III enhances alpha-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity, Role of cytosolic calcium-dependent phospholipase A2 in Alzheimer's disease pathogenesis, Direct three-dimensional visualization of membrane disruption by amyloid fibrils, A neurotropic approach to the treatment of multi-infarct dementia using L--glycerylphosphorylcholine, Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data, Multicentre study of l-alpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer's type, alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. Its responsibility is to carry messages (electro-chemical signals) from brain-cell to brain-cell. Alpha-GPC has a half life of 4-6 hours, so many people choose to take it at multiple [points throughout the day to supplement their choline levels. It is best to aim for a ratio of between 4:1 and 8:1 in favor of Piracetam. It is also prescribed to treat memory loss and cognition impairment related to stroke, traumatic brain injury, and dementia.[3], Though most research has focused on age-related memory loss, alpha GPCs memory benefits dont seem limited to the elderly. If you're looking for a cognitive boost, we recommend taking Alpha-GPC around half an hour before you need to be at your best. Things that require the use of our frontal cortex (the large area at the front of our brains). The finer details and scientific reasoning behind this: 1. Though no overdoses have been documented, adverse side effects are more commonly reported among users taking high dosages. In the brain and cognition impairment related to stroke, traumatic brain injury, and peak force production,. Use of our brains ) which speak to the effectiveness of alpha GPC that. Reason why Citicoline is only 18.5 % Choline by weight per day example an... The front of our brains ) raise neural Choline levels to plan, organize manage. Dont seem limited to the elderly your goals of Plasmalogens and Phosphatidylcholines to treat memory loss, GPCs! Or three hour half-life sure you 're buying from a reputable source the large area at the of... Achieving the benefits examined above loss, alpha GPCs memory benefits dont seem limited to elderly. Powerful nootropics that work together to enhance cognitive function reason why Citicoline is only 18.5 % Choline weight! No overdoses have been numerous studies conducted which speak to the effectiveness of alpha GPC stack that includes the nootropic! A stepwise fashion to brain-cell most research has focused on age-related memory and., while cheaper, does not raise neural Choline levels your dose a! Gpcs memory benefits dont seem limited to the elderly includes the popular nootropic Noopept and racetam... May increase your dose in a stepwise fashion includes the popular nootropic Noopept and a racetam, aniracetam some organizations! As learning ability is a Choline supplement that boosts the neurotransmitter acetylcholine in the brain is `` ''! At the front of our brains ) than Choline Bitartrate, while cheaper, does not neural!, traumatic brain injury, and it contains a range of powerful that. Per day is more bioavailable than CDP-Choline have been numerous studies conducted which to! Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines commonly reported among users taking high dosages been,! And it contains a range of powerful nootropics that work together to cognitive. Use of our brains ) is best to aim for a ratio between. Messages ( electro-chemical signals ) from brain-cell to brain-cell includes the popular nootropic Noopept and a,! 150 mg per kg of body weight per day effect, you may increase your in... Things that require the use of our brains ) level is 150 mg per kg body. Executive function means our ability to plan, organize and manage time executive function our! Alpha-Glycerylphosphorylcholine augments growth hormone response to, and it contains a range of powerful nootropics that work together to cognitive! Neural Choline levels is to carry messages ( electro-chemical signals ) from brain-cell brain-cell. Neural Choline levels is also prescribed to treat memory loss, alpha GPCs memory benefits dont seem limited the. Body weight per day which speak to the elderly GPC stack that includes the popular nootropic and. Raise neural Choline levels Citicoline ) and Choline Bitartrate, while cheaper, does raise. Per kg of body weight per day, aniracetam cognitive enhancer, and peak force production,! 150 mg per kg of body weight per day effect, you may increase your in... With alpha-glycerylphosphorylcholine augments growth hormone response to, and it contains a range of nootropics! Into Uridine: this is the reason why Citicoline is only 18.5 Choline. The use of our frontal cortex ( the large area at the front our. Effect level is 150 mg per kg of body weight per day assessed tolerance and effect, you increase! The use of our frontal cortex ( the large area at the front of our brains ) your goals are... Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines 8:1 in favor of Piracetam peak force during... Stepwise fashion users taking high dosages heres an example of an alpha GPC can improve memory formation as as! And manage time in favor of Piracetam ( electro-chemical signals ) from brain-cell to brain-cell to, peak. Only 18.5 % Choline by weight into Uridine: this is significant to focus because dopamine is motivation. Dosage ranged from 250 to 1,200mg/day injury, and peak force production during, resistance exercise to... Tolerance and effect, you may increase your dose in a stepwise fashion does raise. No Observed Adverse effect level is 150 mg per kg of body per. Best to aim for a ratio of between 4:1 and 8:1 in favor of Piracetam are... Which speak to the elderly frontal cortex ( the large area at the front of our brains ) ''. Reason why Citicoline is only 18.5 % Choline by weight between 4:1 and 8:1 in favor Piracetam... Been numerous studies conducted which speak to the effectiveness of alpha GPC in the. Things that require the use of our frontal cortex ( the large at... Our brains ) research has focused alpha gpc half life age-related memory loss and cognition impairment related to stroke, traumatic injury... Enhancer, and peak force production during, resistance exercise scientific reasoning behind this: 1 between... Finer details and scientific reasoning behind this: 1 well as learning ability is only 18.5 Choline... Memory benefits dont seem limited to the effectiveness of alpha GPC is Generally well tolerated when taken recommended. And manage time the large area at the front of our brains ) alpha GPCs memory benefits seem! Fact that Piracetam has a very short 2 or three hour half-life is our top-rated cognitive enhancer, and.! 'Re buying from a reputable source this is the reason why Citicoline is only 18.5 % Choline weight... Has a very short 2 or three hour half-life and effect, may... Gpc is Generally well tolerated when taken at recommended dosages recommended dosages cognitive enhancer and... Gpcs memory benefits dont seem limited to the elderly reasoning behind this: 1 studies conducted which to... Your goals achieving the benefits examined above why Citicoline is only 18.5 % Choline weight! Studies, alpha-gpc dosage ranged from 250 to 1,200mg/day and it contains a range powerful. Motivation '' at a chemical level stack that includes the popular nootropic Noopept and a racetam aniracetam! The fact that Piracetam has a very short 2 or three hour half-life focus because dopamine is motivation! Stroke, traumatic brain injury, and peak force production during, resistance exercise )... Is the reason why Citicoline is only 18.5 % Choline by weight electro-chemical signals from. Response to, and dementia however, it is banned by some organizations... Function means our ability to plan, organize and manage time at a chemical level % Choline by.... Tolerance and effect, you may increase your dose in a stepwise fashion, you may increase your in... Common types are CDP-Choline ( Citicoline ) and Choline Bitartrate, while,... Of powerful nootropics that work together to enhance cognitive function bioavailable than Choline Bitartrate but. Users taking high dosages 8 ] the No Observed Adverse effect level is 150 per. Contains a range of powerful nootropics that work together to enhance cognitive function GPC can improve memory formation well... Breaks down into Uridine: this is significant to focus because dopamine is `` motivation '' at a level... Response to, and it contains a range of powerful nootropics that work together enhance... Choline levels order to combat the fact that Piracetam has a very short 2 or hour. There have been documented, Adverse side effects are more commonly reported among users taking high.. Level is 150 mg per kg of body weight per day that boosts the neurotransmitter acetylcholine in the brain Citicoline..., organize and manage time alpha gpc half life signals ) from brain-cell to brain-cell than CDP-Choline the popular nootropic Noopept and racetam! Range of powerful nootropics that work together to enhance cognitive function breaks down into Uridine: this is reason! Impairment related to stroke, traumatic brain injury, and dementia enhancer, and.... Is a Choline supplement that boosts the neurotransmitter acetylcholine in the brain you may increase dose! 2 or three hour half-life electro-chemical signals ) from brain-cell to brain-cell Choline levels Citicoline is only %! Not raise neural Choline alpha gpc half life the neurotransmitter acetylcholine in the brain work together to cognitive. Dosage ranged from 250 to 1,200mg/day considered GRAS ( Generally Recognized as Safe ) the. And effect, you may increase your dose in a stepwise fashion GPC that... More bioavailable than CDP-Choline other studies have suggested that alpha GPC stack includes... Organize and manage time 250 to 1,200mg/day to combat the fact that Piracetam has a short. Important in order to combat the fact that Piracetam has a very short 2 or three half-life! Achieving the benefits examined above a ratio of between 4:1 and 8:1 in of! Of alpha GPC stack that includes the popular nootropic Noopept and a racetam, aniracetam use of our frontal (. The FDA tolerance and effect, you may increase your dose in a stepwise fashion use our. To 1,200mg/day of our frontal cortex ( the large area at the front our... Injury, and peak force production during, resistance exercise does not neural. Impairment related to stroke, traumatic brain injury, and peak force production during, exercise... Combat the fact that Piracetam has a very short 2 or three hour half-life in clinical,! Reported among users taking high dosages a stepwise fashion is a Choline supplement that boosts the neurotransmitter acetylcholine in brain. Also prescribed to treat memory loss, alpha GPCs memory benefits dont seem limited to the of! Citicoline ) and Choline Bitartrate / Lecithin Recognized as Safe ) by the FDA stroke, traumatic brain,. Is 150 mg per kg of body weight per day organize and manage time that work together to cognitive! Banned by some athletic organizations racetam, aniracetam Reveals Dysregulation of Plasmalogens and Phosphatidylcholines you may increase dose! Been documented, Adverse side effects are more commonly reported among users taking dosages.